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Parkinson on-off fluctuations

Parkinson's on-of fluctuations and cognitive impairments treatment

Parkinson’s disease: The main way of Parkinson’s disease treatment is L-DOPA, which provides dopamine to the brain in order to overcome dopamine deficiency that occurs in Parkinson’s disease. In advanced stages of the disease, patients are affected with On-Off fluctuations (late motor complications), which can be overcome by a continuous delivery of L-DOPA.

To date, continuous delivery of L-DOPA is done by Duodopa, which is invasive and inconvenient. Lasting Effect is developing a unique formulation of L-DOPA prodrug, which can be loaded into the tablet and released continuously in the oral cavity.
Thus, enabling to maintain constant L-DOPA blood levels that have been shown to be effective in alleviating late motor complications in Parkinson’s disease.
Cognitive malfunction: Another formulation, which is particularly suitable for the Lasting Effect’s tablet, is a combination of two clinically approved drugs, one of which is neuroprotective as well as cognitive enhancer and the other has beneficial effect in treating Parkinson’s disease, particularly alleviating involuntary movements and at the same time it also enhances and prolongs the effect of the first drug.
This drug combination is particularly suitable for buccal release as one component is well absorbed via the oral mucosa and the second component is well absorbed along the gastrointestinal tract.
The tablet with this drug combination can be used for the treatment of Parkinson’s disease as well as for the treatment of dementias, such as those that occur in Parkinson’s disease, minimal cognitive impairment and Alzheimer’s disease.

market size and trends

  • Parkinson Disease Market 2023 – US$ 5.41 Billion
  • Global Growth Rate – 12.2%Growing senior population – 1.4 b in 2030
  • Parkinson disease effect 1% of population over 60, 5% over 85

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