Technology

What is Buccal Delivery ?

Buccal and Transmucosal delivery intended for delivering drugs topically (locally) or systemically through the oral mucosa.
Buccal delivery market size: 3.88 billion USD
Annual market growth: 9.8%
Current major Indications: Pain Management, Smoking Cessation, Angina Pectoris, Cough

One basic platform for wide range of active materials and applications.
Ability to load and dissolute oil-soluble materials on a water soluble environment.
Transmucosal absorption path - has been found to be 3-4 times more affective then transdigestive absorption path.
Possible night usage.
Up to 8 hours of constant, linear release time.
Prolonged time of topical direct contact between the active materials and the inflamed tissue.
Good patient compliance due to adhesiveness, significant reduction in the weight and size and bitter tastes screening, generating desensitization effect.
The tablet undergo safety, efficacy and clinical trials.

One basic platform for wide range of active materials and applications.
Ability to load and dissolve oil-soluble materials in a water-soluble environment.
Transmucosal absorption path - has been found to be 3-4 times more affective then transdigestive absorption path.
Possible night usage.
Up to 8 hours of constant, linear release time.
Prolonged time of topical direct contact between the active materials and the inflamed tissue.
Good patient compliance due to adhesiveness, significant reduction in the weight and size and bitter tastes screening, generating desensitization effect.
The tablet undergo safety, efficacy and clinical trials.

Put tablet in mouth and wet in saliva.
Place the tablet in convenient place on the inner cheek or gum in the lower part of the oral cavity (where most of the saliva glands located), where it will be adhered. It is possible to move the tablet during usage.
After buccal adhesion and contact with saliva, the tablet releases chosen taste and smell compounds which stimulates the saliva glands to generate saliva.
The saliva dissolves the tablet and active material that was loaded on it.
The active ingredients, continuously and linearly released until the user decides to take it out, up to 8 hours.

Put tablet in mouth and wet in saliva.
Place the tablet in convenient place on the inner cheek or gum in the lower part of the oral cavity (where most of the saliva glands located), where it will be adhered. It is possible to move the tablet during usage.
After buccal adhesion and contact with saliva, the tablet releases chosen taste and smell compounds which stimulates the saliva glands to generate saliva.
The saliva dissolves the tablet and active material that was loaded on it.
The active ingredients, continuously and linearly released until the user decides to take it out, up to 8 hours.

Extended-release dissolution process based on generating saliva by interchangeable taste and smell compounds
Enhanced dissolution technology
Minimizing the extended-release technology
One basic solution for a wide range of active materials
Food grade (GRAS) and FDA IID of the delivery system
Systemic absorption through the oral cavity
Possibility to control the dissolution rate and time
Buccal and transmucosal delivery of both hydrophobic and hydrophilic APIs
Adhesion of the product on the inner chick or gum, with easy removal option
Dramatically reduced drug dosage
Possible night usage